LEVERAGING HETEROGENEITY IN ACUTE LEUKEMIAS
Using bulk and single cell genomic approaches, our group aims to understand how recurrent genetic events alter the transcriptome and shape the hierarchy and plasticity of tumor and immune cells in acute leukemia. Ultimately, our goal is to perturb specifically these altered states to reveal context-specific vulnerabilities. We also aim to characterize the evolutionary landscape of mutations that predispose to leukemia in the Québec population. This will in turn help to better understand the underlying cooperative events in these subtypes of leukemia and identify new rationales for targeted therapies.
THE TRANSCRIPTOMIC LANDSCAPE AND DIRECTED CHEMICAL INTERROGATION OF MLL-REARRANGED ACUTE MYELOID LEUKEMIAS.
Lavallée VP, Baccelli I, Krosl J, Wilhelm B, Barabé F, Gendron P, Boucher G, Lemieux S, Marinier A, Meloche S, Hébert J and Sauvageau G.
Nature Genetics 2015. 47(9), 1030-1037.
Sept. 2022: The first official paper from the lab is now available here: Blood Adv - NPM1
May 2022: We are hiring! More details at the bottom of this page.
April 2022: CONGRATULATIONS to Banafsheh for being awarded a Cole foundation fellowship!
February 2022: Severine Landais joins the single cell data analysis platform! More details to follow.
April 2021: CONGRATULATIONS to Simon and Michael who each received an IVADO scholarship to pursue research this summer.
September 2020 Vincent-Philippe Lavallée presents at the 10X Genomics Montreal Single Cell Symposium
August 2020 After receiving a post-doctoral fellowship from the Cole Foundation, Nehme Hachem just received a prestigious IVADO post-doctoral fellowship. Congrats!
June 2020 The Lavallée lab Single-cell platform is now up and running to profile single-cell Omics in cancer and immune tissues! For more information, contact Véronique Lisi or Vincent-Philippe Lavallée
April 2020 The Lavallée lab is awarded a Cole Foundation transition award for the project titled "MAPPING LEUKEMIA PREDISPOSITIONS AND PRELEUKEMIC CLONAL EVOLUTION"
February 2020 The Lavallée lab joins the leucegene multidisciplinary team (leucegene.ca) and the Genome Canada Large-Scale Applied Research Project grant to study cellular heterogeneity in AML patients
Research Associate - Senior Research Scientist
A native Montrealer, Véronique left the Santa Barbara beaches to come back to work in Montréal. After a position at the MUHC, Véronique joined the lab in May 2020. Trained as a computer scientist and a molecular biologist she enjoys learning about and using the possibilities brought forth by technological advances to uncover new biology. In her free time, you will find her scuba diving the St-Lawrence river and the Great Lakes.
Azer pursued a PhD in molecular biology. He joined the lab in January 2020 as part of his master degree of bioinformatics at the Université de Montréal. in January 2022, he got a position as a bioinformatician in the lab. Azer is interested in the study of genetic heterogeneity profiling of AML using bioinformatics tools for new applications in clinical oncology.
Banafsheh’s background is in computer science and bioinformatics. She has worked on various projects from software engineering to genomics analysis. Now she is delving into AML research. When not at work, she loves exploring new hobbies and hiking locations.
Rui obtained her PhD in 2022 from McGill University. Her background is molecular biology and cancer genetics. She is also interested in extending her knowledge in next generation sequencing data analysis. When not at work, she loves practicing yoga.
Single cell data analysis platform
Séverine was trained as a molecular biologist and worked several years as a fundamental scientist and in clinical trial implementation applied to translational research in the fiels of hematopoietic stem cell transplant. She has deep interests in the biology of cancer and in learning how to best analyze its complexity through OMIC sciences, such as single cell sequencing. She is currently a student of the Bioinformatics’ Master program at University of Montreal (concentration ‘Statistics and Machine Learning’).
Maylis graduated from Polytechnique Montreal in June 2022 with a Bachelor's degree in Biomedical Engineering. Strongly interested in bioinformatics, she completed an internship in the Lavallée laboratory during the summer of 2021. Thanks to this experience, she then joined the team in September 2022 as part of a master's degree in bioinformatics at the Université de Montréal. Her research interests include machine learning applied to pediatric cancer classification.
Edith graduated as a medical doctor from the University of Liege, Belgium in 2016. After a year of training in paediatrics at the Centre Hospitalier du Luxembourg, she continued her training in clinical biology at the Université Libre de Bruxelles and obtained her specialist degree in 2021. Her training is on paediatrics, onco-haematology and molecular biology. Her current focus is on germline variations predisposing to cancer.
Assistant Professor, Faculty of Medicine, Department of Pediatrics, Université de Montréal
Researcher, CHU Sainte-Justine Research Center
Hematologist, CHU Sainte-Justine
Anissa Djedid - Bioinformatician
Michael Vladovsky - Medical Student
Simon Del Testa - Medical Student
Ève Blanchard - Undergraduate Student in Biotechnology
Thérèse-Marie Poinsignon - Master students in Biomedical Science
Nehme Hachem - Postdoctoral Fellow
We are HIRING
We are looking for students at all levels (M.Sc, PhD and postdoc) to tackle single cell related research projects. One is more computational oriented, the other, more molecular biology oriented. Please contact us if either of these research project interest you or if you already have a research project in mind.