LEVERAGING HETEROGENEITY IN ACUTE LEUKEMIAS

RESEARCH FOCUS

Using bulk and single cell genomic approaches, our group aims to understand how recurrent genetic events alter the transcriptome and shape the hierarchy and plasticity of tumor and immune cells in acute leukemia. Ultimately, our goal is to perturb specifically these altered states to reveal context-specific vulnerabilities. We also aim to characterize the evolutionary landscape of mutations that predispose to leukemia in the Québec population. This will in turn help to better understand the underlying cooperative events in these subtypes of leukemia and identify new rationales for targeted therapies.

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SELECTED PUBLICATIONS

 

Lavallée VP, Baccelli I, Krosl J, Wilhelm B, Barabé F, Gendron P, Boucher G, Lemieux S, Marinier A, Meloche S, Hébert J and Sauvageau G. 

Nature Genetics 2015. 47(9), 1030-1037.

NEWS

April 2021: CONGRATULATIONS to Simon and Michael who each received an IVADO scholarship to pursue research this summer. 

December 2020: We are hiring! More details at the bottom of this page.

 

September 2020 Vincent-Philippe Lavallée presents at the 10X Genomics Montreal Single Cell Symposium  

August 2020 After receiving a post-doctoral fellowship from the Cole Foundation, Nehme Hachem just received a prestigious IVADO post-doctoral fellowship. Congrats! 

June 2020 The Lavallée lab Single-cell platform is now up and running to profile single-cell Omics in cancer and immune tissues! For more information, contact Véronique Lisi or Vincent-Philippe Lavallée

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April 2020 The Lavallée lab is awarded a Cole Foundation transition award for the project titled "MAPPING LEUKEMIA PREDISPOSITIONS AND PRELEUKEMIC CLONAL EVOLUTION" 

February 2020 The Lavallée lab joins the leucegene multidisciplinary team (leucegene.ca) and the Genome Canada Large-Scale Applied Research Project grant to study cellular heterogeneity in AML patients

 

PEOPLE

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Véronique Lisi

Research Associate - Senior Research Scientist

veronique.lisi.chusj@gmail.com

514-345-4931 x6461

A native Montrealer, Véronique left the Santa Barbara beaches to come back to work in Montréal. After a position at the MUHC, Véronique joined the lab in May 2020. Trained as a computer scientist and a molecular biologist she enjoys learning about and using the possibilities brought forth by technological advances to uncover new biology. In her free time, you will find her scuba diving the St-Lawrence river and the Great Lakes.

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Sanny Singh Khurdia

Ph.D student

Sanny is a PhD student with the Université de Montréal joined the Lab in September 2021. Sanny is interested in oncology and genomics, and he is currently studying the cellular regulation of Podoplanin in APL.

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Azer Farah

Master Student

 

A dedicated Tunisian based in Montreal, Azer pursued a PhD in molecular biology. As part of his master of bioinformatics at the Université de Montréal, he joined the lab in January 2020. Currently, he is interested  in the study of mechanisms regulating the gene activity of cancers by transcriptomic profiling using bioinformatics tools for new applications in clinical oncology.

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Séverine Landais

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Michael Vladovsky

Intern

Medical Student at Université de Montréal Michael is testing the academic research waters. He is currently working on mutation annotation in a large leukemia cohort. 

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Simon Del Testa

Intern

Medical Student at Université de Montréal with a bachelor in biochemistry, Simon has a keen interest in everything hematology-oncology related. He's a firm believer that his knowledge in bio-informatics will help him be a better clinician at some point. He is currently working on using Cite-Seq data to assign cellular identity in leukaemia primary samples.

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Assistant Professor, Faculty of Medicine, Department of Pediatrics, Université de Montréal

Researcher, CHU Sainte-Justine Research Center

Hematologist, CHU Sainte-Justine

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